In vivo and in vitro evidence that leptin stimulates the hexosamine biosynthetic pathway (640.9)
نویسندگان
چکیده
منابع مشابه
In vivo and in vitro evidence that chronic activation of the hexosamine biosynthetic pathway interferes with leptin-dependent STAT3 phosphorylation.
We previously reported that a 2-day peripheral infusion of glucosamine caused leptin resistance in rats, suggesting a role for the hexosamine biosynthetic pathway (HBP) in the development of leptin resistance. Here we tested leptin responsiveness in mice in which HBP activity was stimulated by offering 30% sucrose solution in addition to chow and water or by infusing glucosamine. Mice were lept...
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Noninvasive imaging assessment of tumor cell proliferation could be helpful in the evaluation of tumor growth potential, the degree of malignancy, and could provide an early assessment of treatment response prior to changes in tumor size determined by computed tomography (CT), magnetic resonance imaging (MRI), Positron emission tomography (PET), Single-Photon emission computed tomography (SPECT...
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De novo construction of a chitinous cell wall accompanies Blastocladiella emersonii zoospore germination. At least an order of magnitude increase in total hexosamine occurs during germination. This increase is into polymer (chitin) and occurs on schedule in the presence of cycloheximide. Uridine-5'-diphospho-N-acetylglucosamine (UDPGlcNAc), both the end product of hexosamine biosynthesis and a ...
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In the current study, we investigated the role of tribbles homolog 3 (TRIB3) in glucose-induced insulin resistance and whether the induction of TRIB3 by glucose is dependent on the nutrient-sensing hexosamine biosynthetic pathway (HBP) known to mediate glucose toxicity in diabetes. In diabetic rats, TRIB3 expression in skeletal muscle was increased after 10 days of hyperglycemia, and glycemia a...
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مطالعه حاضر با هدف بررسی وجود رابطه ی ممکن میان هوشهای زبانی و منطقی زبان آموزان انگلیسی و تعداد و انواع مغلطه های زبانی و شواهد در متنهای استدلالی آنان انجام پذیرفته است.بدین منظور، 70 زبان آموز با سطح زبانی متوسط به بالا از دو موسسه زبان انگلیسی در ایران انتخاب شده و پرسشنامه های مزبوطه را تکمیل نموده و متنی استدلالی نوشتند. متون نوشته شده مورد بررسی قرار گرفته و نمرات پرسشنامه ها محاسبه شده ...
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ژورنال
عنوان ژورنال: The FASEB Journal
سال: 2014
ISSN: 0892-6638,1530-6860
DOI: 10.1096/fasebj.28.1_supplement.640.9